منابع مشابه
Frustration, function and folding.
Natural protein molecules are exceptional polymers. Encoded in apparently random strings of amino-acids, these objects perform clear physical tasks that are rare to find by simple chance. Accurate folding, specific binding, powerful catalysis, are examples of basic chemical activities that the great majority of polypeptides do not display, and are thought to be the outcome of the natural histor...
متن کاملFrustration and hydrophobicity interplay in protein folding and protein evolution.
A lattice model is used to study mutations and compacting effects on protein folding rates and folding temperature. In the context of protein evolution, we address the question regarding the best scenario for a polypeptide chain to fold: either a fast nonspecific collapse followed by a slow rearrangement to form the native structure or a specific collapse from the unfolded state with the simult...
متن کاملTopological Frustration and the Folding of Interleukin-1b
0022-2836/$ see front matter q 2005 E Abbreviations used: IL-1b, interle molecular dynamics; MC, multicano relative contact order; lrc, long rang E-mail address of the correspond [email protected] The cytokine, interleukin-1b (IL-1b), adopts a b-trefoil fold. It is known to be much slower folding than similarly sized proteins, despite having a low contact order. Proteins are sufficiently well d...
متن کاملFolding funnels and frustration in off-lattice minimalist protein landscapes.
A full quantitative understanding of the protein folding problem is now becoming possible with the help of the energy landscape theory and the protein folding funnel concept. Good folding sequences have a landscape that resembles a rough funnel where the energy bias towards the native state is larger than its ruggedness. Such a landscape leads not only to fast folding and stable native conforma...
متن کاملMechanical frustration and spontaneous polygonal folding in active nematic sheets.
We analyze the bending response to light or heat of a solid nematic disk with a director twisted from being radial on the upper surface to be azimuthal on the lower. We find a number of curl lobes determined purely by the geometry of the mechanical frustration that arises during the response.
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2018
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2017.09.006